How a Physician in the Licensed Regenexx Network Differs from Other Clinics

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Published in The Ospina Orthopedic Blog ~ 6 min read ~ Last Updated: November 18, 2025



Navigating the World of Regenerative Medicine

Regenerative medicine is changing the way we treat orthopedic injuries, but with its rise in popularity comes a confusing array of options. From chiropractic offices offering "stem cell" injections to spa-like clinics promising miracle cures, it can be hard to know who to trust.

At Ospina Medical, we are proud to be part of the select group of physicians in the licensed Regenexx network. This distinction is not just a label; it represents a commitment to rigorous standards, advanced technology, and data-driven care that you simply will not find at independent clinics.


1. Advanced Lab Processing vs. Bedside Machines

Most clinics use simple, automated bedside centrifuges to create Platelet-Rich Plasma (PRP). These "one-size-fits-all" machines typically produce lower concentrations (2-5x baseline) and often leave behind red blood cells, which can cause unnecessary inflammation (Red PRP).


As a Regenexx provider, Dr. Matthew Kohler has access to a flexible and advanced lab platform. This allows us to create PRP by Regenexx and Bone Marrow Concentrate containing stem cells that are customized to your specific needs. We can remove inflammatory contaminants and achieve much higher concentrations of healing cells—up to 10-20 times higher than baseline. Research shows that in older patients, these higher concentrations are often required to stimulate tissue repair effectively.


2. Your Own Cells vs. "Off-the-Shelf" Products

Many clinics market amniotic or umbilical cord products as "stem cell therapy." However, independent testing by major universities and the Regenexx lab has repeatedly shown that these bottled products contain no live, functional regenerative cells. They are essentially dead tissue products that may contain some growth factors but lack the living machinery to repair tissue.


Regenexx procedures exclusively use your body’s own living cells—harvested fresh and used immediately. Bone Marrow Concentrate, which contains stem cells, is the only source of live, functional mesenchymal stem cells that is compliant with FDA regulations in the United States. We believe in using what works: your own biology.


3. The Importance of Image Guidance

Injecting these powerful solutions requires pinpoint accuracy. Missing the joint or tendon by even a few millimeters can mean the difference between success and failure. Physicians in the licensed Regenexx network undergo hundreds of hours of specialized training through the Interventional Orthobiologics Foundation (IOF). We use advanced fluoroscopy and ultrasound to place cells into specific tears, ligaments, and joint spaces that general practitioners often cannot see or reach.


4. Transparency and Data

While others rely on testimonials, Regenexx relies on data. We maintain the world’s largest patient registry for interventional orthopedics, tracking tens of thousands of procedures. This data is published online, allowing you to see real-world outcomes for your specific condition before you even book an appointment. We track safety and efficacy rigorously, something rarely found in independent clinics.


Choose Expertise, Not Hype

Your orthopedic health is too important to gamble on unproven methods. By choosing Ospina Medical and the Regenexx network, you are choosing a physician who is held to the highest standards in the field. Schedule a consultation with Dr. Matthew Kohler to experience the difference that expert, data-driven care can make.


A Riley Publication ~ Branded Thought Leadership by Riley Partners and Publications, Inc.

Medically Reviewed by: Matthew Kohler, MD



References
Berger, D. R., et al. (2018). Platelet lysates from aged donors promote human tenocyte proliferation and migration in a concentration-dependent manner. Bone & Joint Research, 7(9), 539-546.
Centeno, C. J., et al. (2015). A prospective multi-site registry study of a specific protocol of autologous bone marrow concentrate for the treatment of shoulder rotator cuff tears and osteoarthritis. Journal of Pain Research, 8, 269.
Centeno, C. J., et al. (2021). Use of Bone Marrow Concentrate to Treat Pain and Musculoskeletal Disorders: An Academic Delphi Investigation. Pain Physician, 24, 263-273.
Panero, A. J., et al. (2019). Cryopreserved Amniotic Membrane and Umbilical Cord Particulate for Management of Pain: A Systematic Review. Pain Physician, 22, E557-E572.
Veronesi, F., et al. (2013). Stem cells from umbilical cord and placenta for musculoskeletal tissue engineering. Cells Tissues Organs, 198(3), 175-193.

Disclaimer
This article is for informational purposes only and does not constitute medical advice. Please consult with your healthcare provider for any personal health concerns.


* All information subject to change. Images may contain models. Individual results are not guaranteed and may vary.